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Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
article 17 sep 2019

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

Geschreven door Tijs Vandoorne
This article is only available in English. Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (iPSCs) versus iPSC-derived MNs and subsequently compared MNs from ALS patients carrying FUS mutations to their CRISPR/ Cas9-corrected counterparts. Download the full article here below.
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
pdf - 1.48 MB